The innovations brought in healthcare and assistance network of healthcare system and their translation into clinical practice are seeing an exponential increase, thanks to a continuous progress and improvement of new generation of technologies for DNA sequencing and a progressive decrease in the financial resources needed for their use. Today, the limit to overcome is the lack of large research infrastructures that are able to handle and, consequently, interpret the big data generated by these technologies. This technologically advanced sector also has repercussions on scientific research (including applied research) and also on the economic development process. A modern, effective and efficient healthcare system depends more and more on digital innovation. The systemic management of big data is fundamental for archiving, reprocessing and transforming it into new information. Collecting and analyzing health data allows to manage patients in a more targeted manner, make accurate diagnoses, for example for socio-demographic assessments (so as to reduce the costs associated with health services and also predict and prevent epidemics). The main product/services that will characterize the main Hub will be the following:

• Large scale analysis: integrative analysis on generated and remote acquired data
• Big data storage
• Planning and design of a data sharing platform
• Web-site construction and updating